|
levitra dosage 00 mg once daily) produced a 10-fold increase in vardenafil AUC and a 4-fold increase in Cmax when co-administered with LEVITRA (5 mg) in healthy volunteers. A 5-mg LEVITRA dose should not be exceeded when used in combination with 200 mg once daily ketoconazole. Since higher doses of ketoconazole (400 mg daily) may result in higher increases in Cmax and AUC levitra dosage, a single 2.5 mg dose of LEVITRA should not be exceeded in a 24-hour period when used in combination with ketoconazole 400 mg daily (see WARNINGS and DOSAGE AND ADMINISTRATION). HIV Protease Inhibitors: Indinavir (800 mg t.i.d.) co-administered with LEVITRA 10 mg resulted in a 16-fold increase in vardenaf levitra dosage.
levitra dosage Il AUC levitra dosage, a 7-fold increase in vardenafil Cmax and a 2-fold increase in vardenafil half-life. It is recommended not to exceed a single 2.5 mg LEVITRA dose in a 24-hour period when used in combination with indinavir (see WARNINGS and DOSAGE AND ADMINISTRATION). Ritonavir (600 mg b.i.d.) co-administered with LEVITRA 5 mg resulted in a 49-fold increase in vardenafil AUC and a 13-fold increase in vardenafil Cmax. The interaction is a consequence of blocking hepatic metabolism of vardenafil by ritonavir levitra dosage, a highly potent CYP3A4 inhibitor levitra dosage, which also inhibits CYP2C9. Ritonavir significantly prolonged the half-life of vardenafil to 26 hours. Consequently levitra dosage, it is recommended not to exceed a single 2.5 mg LEVITRA dose in a 72-hour period when used in combination with ritonavir (see WARNINGS and DOSAGE AND ADMINISTRATION). Other Drug Interactions: No pharmacokinetic interactions were observed between vardenafil and the following drugs: glyburide levitra dosage, warfarin levitra dosage, digoxin levitra dosage, Maalox levitra dosage, and ranitidine. In the warfarin study levitra dosage, vardenafil had no effect on the prothrombin time or other pharmacodynamic parameters. Effects of LEVITRA on other drugs In vitro studies: Vardenafil and its metabolites had no effect on CYP1A2 levitra dosage, 2A6 levitra dosage, and 2E1 (Ki >100 mM). Weak inhibitory effects toward other isoforms (CYP2C8 levitra dosage, 2C9 levitra dosage, 2C19 levitra dosage, 2D6 levitra dosage, 3A4) were found levitra dosage, but Ki v.
levitra dosage Nded not to exceed a single 2.5 mg LEVITRA dose in a 72-hour period when used in combination with ritonavir (see WARNINGS and DOSAGE AND ADMINISTRATION). Other Drug Interactions: No pharmacokinetic interactions were observed between vardenafil and the following drugs: glyburide levitra dosage, warfarin levitra dosage, digoxin levitra dosage, Maalox levitra dosage, and ranitidine. In the warfarin study levitra dosage, vardenafil had no effect on the prothrombin time or other pharmacodynamic parameters. Effects of LEVITRA on other drugs In vitro studies: Vardenafil and its metabolites had no effect on CYP1A2 levitra dosage, 2A6 levitra dosage, and 2E1 (Ki >100 mM). Weak inhibitory effects toward other isoforms (CYP2C8 levitra dosage, 2C9 levitra dosage, 2C19 levitra dosage, 2D6 levitra dosage, 3A4) were found levitra dosage, but Ki va.
levitra dosage 
|
